LONDON--(MARKET WIRE)--Oct 6, 2008 --

 
NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company


Smith & Nephew plc


2. Name of shareholder having a major interest


Prudential plc


3. Please state whether notification indicates that it is in
respect of holding of the shareholder named in 2 above or in
respect of a non-beneficial interest or in the case of an
individual holder if it is a holding of that person's spouse
or children under the age of 18


Non-beneficial


4. Name of the registered holder(s) and, if more than one holder,
the number of shares held by each of them


Prudential Plc



5. Number of shares / amount of stock acquired


None


6. Percentage of issued class



7. Number of shares / amount of stock disposed



8. Percentage of issued class



9. Class of security


Ordinary shares of US 20 cents


10. Date of transaction


01.10.2008


11. Date company informed


03.10.2008


12. Total holding following this notification


26,628,151


13. Total percentage holding of issued class following this
notification


Less 3%


14. Any additional information


Prudential plcno longer have a notifiable interest in Smith &
Nephew


15. Name of contact and telephone number for queries


Gemma Parsons - Assistant Company Secretary

020 7960 2228


16. Name and signature of authorised company official responsible
for making this notification


Gemma Parsons - Assistant Company Secretary


Date of notification


06.10.2008


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