Item 1.01. Entry into a Material Definitive Agreement

On September 30, 2009, CombiMatrix Corporation ("CombiMatrix" or the "Company") entered into a supply agreement (the "Supply Agreement") with Illumina, Inc., a provider of systems for the analysis of genetic variation and biological function ("Illumina"). Pursuant to the Supply Agreement, CombiMatrix has agreed to sell to Illumina and its affiliates certain CombiMatrix products for use in or for sale with Illumina products and applications. Subject to certain minimum purchase order commitments, the Supply Agreement also gives Illumina an option to purchase exclusive rights to use and sell those CombiMatrix products in a designated field.

Forward-Looking Statements

This Current Report on Form 8-K, including its exhibits, contains forward-looking statements. Forward-looking statements typically are identified by use of terms such as "may," "will," "should," "plan," "expect," "anticipate," "intend," "estimate" and similar words, although some forward-looking statements are expressed differently. Forward-looking statements represent our management's judgment regarding future events. Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. All statements, other than statements of historical fact included in this Current Report on Form 8-K, are forward-looking statements. The Company cannot guarantee the accuracy of the forward-looking statements, and you should be aware that the Company's actual results could differ materially from those contained in the forward-looking statements due to a number of factors, including the statements under "Risk Factors" contained in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission.

---