Item 5.02. Departure of Directors or Certain Officers; Election of Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers
(e) Amendment of The Medicines Company's 2000 Employee Stock Purchase Plan On May 28, 2009, the stockholders of The Medicines Company (the "Company") voted to approve an amendment to the Company's 2000 Employee Stock Purchase Plan (the "ESPP") to increase the number of shares of common stock of the Company authorized for issuance thereunder from 505,500 shares to 805,500 shares. The Company's Board of Directors approved the amendment to the ESPP on February 11, 2009, subject to, and effective upon, approval by the Company's stockholders at the 2009 Annual Meeting of Stockholders. The ESPP permits eligible employees to purchase shares of the Company's common stock at a discount. A more complete description of the terms of the ESPP can be found in Proposal 2 to the Company's definitive proxy statement on Schedule 14A filed with the Securities and Exchange Commission on April 30, 2009 (the "2009 Proxy Statement"). The summary of the ESPP, as amended, is qualified in its entirety by the text of the ESPP, a copy of which is filed as Appendix I to the 2009 Proxy Statement and is incorporated by reference herein. Item 9.01. Financial Statements and Exhibits
(d) Exhibits.

10.1 The Medicines Company's 2000 Employee Stock Purchase Plan, as amended (incorporated by reference to Appendix I to the Company's definitive proxy statement, dated and filed with the Securities and Exchange Commission on April 30, 2009, for the Company's 2009 Annual Meeting of Stockholders).

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