Item 8.01 Other Events

On February 12, 2009, the Company issued a press release and held a conference call providing an update on the Company's previously submitted pegloticase Biologics License Application (BLA). A copy of the press release issued by the Company on February 12, 2009, and a transcript of the February 12, 2009 conference call, are furnished as Exhibits 99.2 and 99.3, respectively, to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits

d) Exhibits See Exhibit Index attached hereto.

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