Item 8.01 Other Events.

Fourth Circuit Affirms Dismissal of Consolidated Class Action Complaint with Prejudice

As previously disclosed by Inspire Pharmaceuticals, Inc. ("Inspire"), a Consolidated Class Action Complaint (the "CAC"), was filed on March 27, 2006 that asserted claims against Inspire and certain of its present or former senior officers or directors as described in Inspire's various reports under the Securities Exchange Act of 1934, as amended. On June 30, 2006, Inspire and the other defendants moved that the court dismiss the CAC on the grounds that it failed to state a claim upon which relief could be granted and did not satisfy the pleading requirements under applicable law. On July 26, 2007, the United States District Court for the Middle District of North Carolina (the "District Court") granted Inspire's and the other defendants' motion and dismissed the CAC with prejudice. On August 24, 2007, the plaintiffs filed an appeal to the United States Court of Appeals for the Fourth Circuit (the "Fourth Circuit").

On December 12, 2008, the Fourth Circuit issued an opinion affirming the judgment of the District Court.