Pressure BioSciences, Inc., (the "Company") terminated eight employees, representing 40% of the Company's workforce, effective November 26, 2008, under a plan of termination described in paragraph 8 of FASB Statement of Financial Accounting Standards No. 146 "Accounting For Costs Associated With Exit or Disposal Activities," pursuant to which charges will be incurred under generally accepted accounting principles (the "Restructuring"). The Restructuring was initiated in connection with the Company's revised corporate strategy of reducing costs to better preserve existing cash.

The Company estimates it will record restructuring charges of approximately $65,000 in the fourth quarter of 2008 in connection with the Restructuring relating to a one-time payment of severance based on years of service, fringe benefits and costs related to the shutdown of the Rockville, MD facility. The majority of these payments will be made in the fourth quarter of 2008.

A copy of the press release issued by the Company on December 1, 2008 announcing the Restructuring is attached hereto as Exhibit 99.1, and is incorporated herein by this reference.

(d) Exhibits

Exhibit Number Exhibit Description

99.1           Press release dated December 1, 2008 of Pressure BioSciences, Inc.
               announcing its restructuring and significant cost reduction
               initiatives.