On August 21, 2007, Cougar Biotechnology, Inc. (the "Company") entered into an amendment to a letter agreement with Charles R. Eyler, the Company's Treasurer and Vice President of Finance, originally dated August 5, 2004. Pursuant to the amendment, Mr. Eyler's annual base salary was increased from $140,000 to $185,000, effective August 23, and the maximum amount of annual discretionary bonus for which Mr. Eyler is eligible was reduced from 50% to 30% of his annual base salary. In addition, the Company awarded a bonus of $70,000 to Mr. Eyler for his services from August 23, 2006 to August 22, 2007.

On August 23, 2007, the Company also issued to Mr. Eyler a 10-year incentive stock option pursuant to the Company's 2003 Stock Option Plan, as amended, to purchase 40,000 shares of the Company's common stock at an exercise price of $22.50, the closing price of the Company's common stock on the date of grant. The options vest in equal annual installments over four years, commencing August 23, 2008.

(d) Exhibits.

Exhibit      Description

10.1         Amendment to Employment Offer Letter by and between the Company and
             Charles R. Eyler dated August 21, 2007